Inherited thrombophilia: Diagnostic approach

Rahem Mahdy Rahem --- Rehab Abdul Sahb Al‑Waeli

Iraq Joural of Hematology المجلة العراقية لامراض الدم
ISSN: 20728069/25432702 Year: 2017 Volume: 6 Issue: 2 Pages: 31-37
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Hemostatic abnormalities include both bleeding and thrombosis disorders. Adherence to mostcommon guidelines for the diagnosis of thrombophilia is recommended especially in some developingcountries. High level of orientation to thrombophilic disorders needs wide spectrum of knowledgeabout the causes, primary or secondary, investigations to most common risk factors, selectingcandidates to investigations, in addition to covering the possibility of multifactorial background ofdisease. Limited data are available that focus on the thrombophilic disorders with imperfect diagnosticcooperation between clinical and laboratory aspects to reach the full picture of these hemostaticabnormalities. In this short review of literature, we considered the most important publications thatassessed the inherited thrombophilia at levels of presentation, diagnosis, and management withfocus on the practical side. The aim of this review is to summarize the most important aspects ofthe thrombophilia presentation, inherited causes, indications for testing, and investigations requiredfor thrombophilic patients


Inherited thrombophilia --- laboratory investigations of thrombophilia --- thromboembolism