A case report of a young female with plasma cells leukemia

Nawshirwan Gafoor Rashid --- Sana Dlawar Jalal

Iraq Joural of Hematology المجلة العراقية لامراض الدم
ISSN: 20728069/25432702 Year: 2017 Volume: 6 Issue: 2 Pages: 94-96
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Plasma cell leukemia (PCL) is a rare and aggressive variant of plasma cell dyscrasias that can occureither de novo (primary) or as a leukemic transformation of end‑stage multiple myeloma (MM). PCL isknown with a poor prognosis and with a different biologic background, clinical, and laboratory features.Primary PCL presents more often with extramedullary involvement, anemia, thrombocytopenia,hypercalcemia, elevated serum 2‑microglobulin, and lactate dehydrogenase levels, in addition toimpaired renal function in comparison with MM. Here, we report a case of a young female who wasadmitted with excessive thirst, polyuria, lower backache, fever, and weight loss over 2 months.Peripheral blood smear showed numerous atypical looking plasma cells, and immunophenotyping onbone marrow (BM) aspirate demonstrated the presence of clonal plasma cells. She was admitted toadult hematology ward in Hiwa Hemato‑Oncology Hospital, Sulaimani, Kurdistan, Iraq and receivedfour cycles of bortezomib, thalidomide, and dexamethasone chemotherapy, followed by two morecycles of dexamethasone, cyclophosphamide, etoposide, and cisplatin, and later, she proceeded toautologous BM transplantation. More details of the case are presented below.


Autologous transplantation --- leukocytosis --- plasma cell leukemia