HEMATOLOGICAL PROFILE OF RATS TREATED WITH QUERCETIN DERIVATIVE AGAINST CARBON TETRACHLORIDE (CCL4 ) TOXICITY

Abstract

The effect of quercetin derivative (1-(-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4 H –chromen-4-ylidene) thiourea coded (QTU) on the hematological profileof Wistarrats induced toxicity with carbon tetrachloride (CCl4) was investigated.Administration intra peritoneal injection of 12.5 mg /kg and 25mg/kg of quercetinderivative (QTU) ,after four weeks of being exposure to CCl4, led to a significantdecrease (p<0.05) in WBC count, with a corresponding increase on PCV and Hb. It wasalso observed that the functional recovery of these blood indices is concentrationdependent.Results of this study revealed a depletion of RBC and a decrease in Packed CellVolume (PCV) and Hemoglobin (Hb),In addition, an elevation in the levels of WhiteBlood Cell (WBC) caused by CCl4 compared to control samples