Effect of paracetamol in chromosomal aberration and sperm abnormalities of germinal cells in white mice

Abstract

Paracetamol is a widely used as analgesic and antipyretic. It is aviable at all pharmacies and you can get it without special medicalprescript over dosage of paracetamol can cause a serious damages likeliver necrosis or muscle atrophy on acute condition it also cause damagesfor kidneys and pancreases functions.The aim of study to detect the cytogenetic effects of paracetamoldrug through using cytogenetic analysis on the germ cells and spermsabnormalitics in white mice.The result showed that two concentration of paracetamol (50 and100) mg/kg caused a reduction in the mitotic index, increasing in thechromosomal aberrations, abnormalities in the sperms shape, reductionin the percent of the viable normal sperm and reduction sperm motility.