Microbial Causes of Urinary Tract Infection and its Sensitivity to Antibiotics at Heevi Pediatric Teaching Hospital/Duhok City

Abstract

Background: Urinary tract infection (UTI) refers to the presence of microbial pathogens within the urinary tract, and it is usually classifiedby the site of infection as the bladder (cystitis), kidney (pyelonephritis), or urine (bacteriuria). Objectives: The objectives of this study wereto determine the etiological bacterial pathogens of UTIs and to identify antibiotic sensitivity patterns of pathogens isolated among age groupsof children. Materials and Methods: In this cross‑sectional study, a random sample of the local registry of Heevi pediatric hospital of thepatients who were diagnosed with UTI and were sent for antibiotic sensitivity between August 2018 and July 2019 was taken for analysis. Sevenhundred and twenty‑two patients were included in the present study whose ages ranged from birth to more than 10 years. Results: The studyshowed that 22.8% and 20.6% of the patients were in >3–5 and 7–10 years of age and majority were females (66.5%). The study revealed that56.2% of the patients had different pathogens, and Escherichia coli was the most common pathogen in the diagnosed patients with UTI. Thepathogens had different frequency in the urine samples. Most of the cultures were sensitive to gentamycin (23.4%), amikacin (27.6%), andnorfloxacin (25.4%). The most resistant cultures were toward trimethoprim (31.2%), cephalothin (32.6%), and cefixime (21.6%). The studyshowed that E. coli was prevalent pathogen in all age groups. The study did show that common antibiotics were not statistically significantlydifferent between male and female patients, including gentamycin (P = 0.145), amoxicillin (P = 0.304), and norfloxacin (P = 0.407). Thecommon antibiotics were more prevalent in >3–5 years group, including gentamycin; amoxicillin; and norfloxacin. Conclusion: This studyfinding showed that E. coli isolates were the predominant pathogens and showed increasing sensitivity pattern to antimicrobial gentamycin,amikacin, and norfloxacin.