HISTOLOGICAL CHANGES IN PLACENTA OF PATIENTS WITH PRE ECLAMPSIA

Abstract

Background: Preeclampsia is a major disease of human reproduction, with 10% of human births being affected, mainly a systemic endothelial disease causing activation of platelets and diffuse ischemic disorders.Objectives: The study aims to demonstrate the histological changes in placenta of women suffering from hypertensive disease. Methods: Placental samples were obtained from 15 healthy uncomplicated pregnancies and 35 pregnancies complicated by intrauterine growth restriction due to sever preeclampsia. Samples were prepared and examined by light microscope.Results: Variable changes have been observed in different patients, including degeneration of most of endothelial cells, degeneration of major trophoblast cells, hyalinization and fibrotic trophoblast cells in some patient sections and fatty infiltration within trophoblast cells in other patient sections.Conclusion: The primary cause of preeclampsia is a disturbed growth of trophoblast cells with the degeneration of major endothelial cells.Key words: Preeclampsia, Placenta, histological changes.