POSSIBLE ROLE OF IL-1-α AND TNF-α IN BREAST CANCER

Abstract

Background: Cytokines have been used as biomarkers in research for prognosis and have been associated with symptoms and adverse outcomes in multiple conditions, including breast cancer.Objectives: To estimate the concentration of IL-1-α and TNF-α in serum of breast cancer (BC) patients compared with control groups and to detect if there is association of serum levels of these interleukins with disease development. Subjects and Methods: The levels of IL-1-α and TNF-α were measured by ELISA method in sera of 45 BC patients, 12 patients with benign breast lesions and 23 apparently healthy controls.Results: Present study was demonstrated that IL-1-α and TNF-α levels were significantly elevated in serum of BC patients as compared with controls (p<0.001), this elevation were significantly associated with poor prognostic factors including advanced stage and estrogen and progesterone receptors-negative status.Conclusions: Evaluation the serum level of IL--α1and TNF-α may be helpful as predictive non-invasive tests for tumor development in breast cancer patients.Keywords: Breast cancer, IL--α1, TNF-α.