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EXPRESSION OF Fas AND FasL IN TROPHOBLASTIC TISSUE OF WOMEN WITH SPONTANEOUS AND INDUCED ABORTION USING INSITU HYBRIDIZATION TECHNIQUE

Abdul-Razzak H. Ahmed عبد الرزاق حردان احمد --- Mohammed R. Ali محمد رزاق علي

IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية
ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 2 Pages: 147-151
Publisher: Al-Nahrain University جامعة النهرين

Abstract

BackgroundApoptosis of trophoblastic cells may play a role in the pathogenesis of abortion, and one mechanism of apoptosis is Fas receptor and legand system.ObjectiveEstimate the level of Fas and FasL in trophoblastic tissue of aborted women.MethodsIn this study, 25 women with spontaneous abortion and 5 women with induced abortion were included from attendants of Gynecology department at Al-Kadhimiya Teaching Hospital in Baghdad. In-situ hybridization (ISH) tests were done to detect the level of expression of Fas and FasL in trophoblastic tissue.ResultsThe highest percentage of expression of Fas and FasL was found in the trophoblastic tissue of females with spontaneous abortion (34.36% for Fas and 31.86% for FasL), while the expression of them was low in induced abortion group (9.2% and 9.4%, respectively).ConclusionThe data strengthen the possibility that the apoptosis of trophoblastic cells via enhanced expression of Fas-FasL system is an important mechanism of spontaneous abortion.Key wordsMiscarriage, Trophblast, Apoptosis, Fas, FasL, ISH.

Keywords

Miscarriage --- Trophblast --- Apoptosis --- Fas --- FasL --- ISH