The effect of chloroquine phosphate on C-reactive protein and erythrocyte sedimentation rate measurement in knee osteoarthritic patients.

Abstract

Osteoarthritis (OA) is the most common articular disease world wide. It isthe result of both mechanical and biological events that destabilize the normalcoupling of degeneration synthesis of articular cartilage and subchondral bone.Rheumatologist often routinely order tests for rheumatoid factor anderythrocyte sedimentation rate (ESR) for all patients with joint complaints aswell as C - reactive protein (CRP) as a laboratory marker important in theassessment of inflammation. Anti malarial drugs are used for treatment of manyrheumatic diseases. Chloroquine phosphate (CQP) was used previously as adisease modifying anti rheumatic drug and in this study its effect appearsthrough decreasing the measurement of erythrocyte sedimentation rate (ESR)and C-reactive protein (CRP) in knee osteoarthritic patients (KOA).Abbreviation: HCQ, hydroxy chloroquine; CQ, chloroquine; DMARD, diseasemodifying anti rheumatic drug; APP, acute phase protein; ACR, AmericanCollege of Rheumatology; RA, rheumatoid arthritis; SLE, systemic lupuserythematosus; RF, rheumatoid factor.