Study on Dissolution test and the correlation factors that lead to different Bioavailability of Drugs

Abstract

The aim of this work is to study the physical and chemical characteristicssolubility testing by using three types of drugs which are: (Clopidegrol tablet,Simvastatin tablet, Chlorpromazine tablet).From different sources (France, Jordan, India, Germany, Creek,Syria and Lebanon) according to American standard (U.S.P30) to obtain theresults to the primary solubility testing data the result of the significant levelcomparison to analysis the variation for the test of equal means of the data ofsolubility as following:1 - The solubility of the French drug is the heights with significant leveldifferences at:A - With a highly significant level (P < 0.01) Compared with the Indianproduct.B - With a non significant level at ( P > 0.05) Compared with Jordanproduct.C - A highly significant level at (P < 0.01) according to the solubility ofJordan product by using Simvastatin.2 - The results of significant difference is based on the highest solubility byusing Clopidegrol drug at (P < 0.01) compared with the Jordan and withsignificant level (P < 0.05) compared with Indian drug .3 - Also the result of significant level comparison given high significant level(P < 0.01) between the German product which gives a high significantdifference level compared with the Greek product and with un significantlevel ( P > 0.05) compared with Indian product .4 - Show that their exist a significant difference (P < 0.05) with the highlysolubility for the Lebanon product compared with Syrian product by alsousing chlorpromazine in similarly test for average reading of solubility byusing t-test.