Kala azar one of the diseases that play role in autoimmune Thyroid diseases

Abstract

Autoimmune thyroid diseases (AITD) are disorders of thyroid glandcaused by an immune system defect known as autoimmunity. In autoimmunitythe immune system errs in its response and targets the body's tissues and cells.To confirm the possible role of Kalaazar disease in complications ofautoimmune thyroid diseases (autoimmune thyroglobulin AITG andautoimmune thyroid peroxidase AITPO in this study, 50 patients (male andfemale) were investigated afflicted with Kalaazar disease, their ages of (< 1-15)years. They were taking from Central Public Health Laboratory .The controlgroup consisted of 25 healthy subjects comparable for age and sex of studygroups. The detection of Leishmania donovani parasite test was done by usingdipstick rK39, whereas autoimmune thyroid diseases (AITG and AITPO) testsestimated in the same patients by using immunofluorescent method (IFAT). Theresults indicated that patients were suffering from spleenomagaly, hepatomegalyand decreased in white blood cells and hemoglobin percents. The results ofIFAT tests showed that 32 patients were evaluated to have AITD with percent64 % (AITG and AITPO) of all the subjects enrolled in this study: 40% of thepatients have AITG (20 out of 50 patients) and 24% have AITPO (12 out of 50patients). And the percent of (AITG +AITPO) with accompanying was (11,22%). The study showed there was a highly significant differences (p<0.01)among patients with AITG, AITPO comparable with other groups.The aim of this study was to detect the effective role of Kalaazar disease inautoimmune thyroid diseases.