Study Effects of Citrullus colocynthis Seeds on Blood Glucose Level in Rats

Abstract

The antidiabetic activity of Citrullus colocynthis is still unclear. The present investigation was conducted as an attempt to evaluate the effect of Citrullus colocynthis seeds in serum glucose level for normal and diabetic rats. Results were indicated that an treatment with a powder of the seeds of Citrullus colocynthis as a water suspension orally for four weeks daily with the concentrations (100, 200, 300 mg/kg of body weight) produced non significant decreasing in the level of serum glucose of normal rats, but the concentrations (300 and 600mg/kg of body weight) when given to induced – diabetic rats were showed a significant decrease in the level of serum glucose. The results obtained from this study suggest that the water suspension of Citrullus colocynthis seeds may be used for the treatment of diabetes mellitus after the sure that there is no side effects for it.