Lipid Peroxidation and Oxidative Stress in Patients with Fibromyalgia Syndrome


ABSTRACT:BACK GROUND:Fibromyalgia (FMS) is a common, chronic widespread pain syndrome usually associated with other somatic and psychologic symptoms including fatigue, sleep disturbances, cognitive difficulties Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radical in the body system.OBJECTIVE:To evaluate and compare the antioxidants and lipid peroxidation in patients with fibromyalgia and healthy control.PATIENTS AND METHOD;The study has included sixty patients with FMS (40 females and 20 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic in Medical City- Baghdad Teaching Hospital- Rheumatology& Rehabilitation Consultation Unit. Laboratory parameters included: uric acid,albumin,caeruloplasmin,total thaiol,malondiaaldehyde(MDA) and peroxinitrate(ONOO¯ ).RESULTS:MDA and uric acid levels in serum of patients with fibromyalgia were significantly higher than in the control group. While the levels of ONOO¯ GSH,CP,albumin in serum of patients with fibromyalgia were significantly lower than in healthy control.CONCLUSION:oxidative stress may have a role in the pathophysiology of fibromyalgia syndrome.