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Diabetes Mellius is The Predominant Risk Factor of Dupuytren , s Disease in Babylon Aprospective Matched Case Control Study

Sabah J. AL-Rubiae

Medical Journal of Babylon مجلة بابل الطبية
ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: 261-274
Publisher: Babylon University جامعة بابل

Abstract

In Merjan teaching hospital we recorded (3200) cases of hand complaints in period from Nov. 2002 – June 2004. Of them, Dupuytren’s hand diseases were represented in (84) cases 2.6% the (study group). which were investigated for the association and severity, with diabetes mellitus ,smoking and other risk factors , this study group also were matched for age and gender with other three groups : Group I: (230) Patients who had diabetes mellitus for more than (10) years duration, who were neither smokers nor alcoholic or epileptics. Group II: (300 ) community controls , who were smokers “ more than 20 cigarette per day for more than 10 years “,who were neither diabetics nor alcoholic or epileptics . Group III: ( 420 ) community controls , who were randomly selected . The results showed that the Dupuytren’s disease is strongly associated with diabetes mellitus, where in study group: 25% of Dupuytren’s were diabetics, while 11.9% of Dupuytren’s were smokers 2.3% were epileptics on phenytoin. Group I: 9.5% of diabetics patients had got Dupuytren’s Group II :2.6% of smokers had got Dupuytren’s disease . Group III: The total number of Dupuytren's disease were ( 7 ) cases 1.6 %. Grouped as follow ( 4 ) cases were diabetics , ( 1 ) case was smokers. And (2) cases had not apparent risk factors . On basis of the results, the Dupuytren’s disease is strongly associated with diabetes mellitus, although milder , appeared earlier in age than other risk factors and mostly bilateral. There was no significant difference regarding incidence between different types of jobs , or between dominant hands and non dominant ones . The purpose of the present prospective case matched study , is to elucidate the role of diabetes mellitus as main predisposing risk factor of Dupuytren’s disease In Babylon.