Fulltext

Tumor Suppressor Gene( E-Cadherin )and Its Role in Normal and Malignant Cells

Ali Hassan Al-Timimi

Medical Journal of Babylon مجلة بابل الطبية
ISSN: 1812156X 23126760 Year: 2004 Volume: 1 Issue: 3-4 Pages: i-xiii
Publisher: Babylon University جامعة بابل

Abstract

Tumor suppressor genes (E-cadherin) are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products. The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.