دراسة نسيجية – وظيفية لكبد وكلى الجرذان المعاملة بجرع مختلفة من كبريتات الصوديوم

Abstract

The present study was carried out for determine the toxification effected to sodium Sulfate in liver and kidneys albino rats.The expermintal animals were divided randomly into three groups,each group included(20)animals.the first group administrated sodium sulfate for(30)days at concentration (25)body weight,while the second group injected with sodium sulfate at concentratio(50)milligram/kilogram,while the third group(control group)injected with normal saline at the same prrieod,and the injection was every (48)hours.and the injection was tntraparitonial.The present study reveald:1_A significant decrease(P<0.05)in the total body weight and in the organs weight at concentration (25) milligram/kilogram of sodium sulfate.2_A significant increase in the total body weight,liver and kidneys((P<0.05)at concentration (50) milligram/kilogram of sodium sulfate.3_The histological changes for treated with sodium sulfate at concentration (50) milligram /kilogram was harder than in liver and the medulla of kidney comparison with cortex.dilation in sunsoides of the liver and hypertrophy,conjestion of central vein,as well as degeneration and necrosis of hepatocytes.while the cortex of kidney treated with sodium sulfate at concentration (50) milligram/kilogram was lower than in medulla,graduated from conjestion in arteries and veins of kidneys,degeneration and necrosis in hepatocytes that coverd the distal and proximal tubules.and the histological changes was necrosis in cells coverd the tubuled of urine and dilation of kidneys artery and hemorrihage in medulla.