Effect of sinaflor drug)NaF( on reproductive system in adult male mice

Abstract

The trail conducted to study the effect of sinaflor drug Syrian origin which contain 1 mg [NaF] on the reproductive system of twenty adult male mice. . the mice were divided randomly in to four groups .first group were given 0.500 ppm fluorine in drinking water second and third groups were given 0.250 and 0.125 ppm fluorine in drinking water respectively .The control group was given drinking water .The experiment continue fifty days and mice were scarified at the end of the period to study the fertility parameters Results showed that Sperm count and, dead sperm percentage had significant difference's( p<0.05 )in treated mice groups compared with control, while. Abnormal sperm and abnormal acrosome percentages had no differences between treated groups and control . Here was a significant difference( p<0.05) in sera testosterone level between the treated groups compared with control group .fluorine accumulation in the testes was also measured and found the accumulation is increased and follow the increasing concentration of NaF in drinking water.