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SERUM CALCIUM, INORGANIC PHOSPHATE, URIC ACID, COPPER, ZINC AND MAGNESIUM IN OSTEOARTHRITIS PATIENTS

Jamal Ahmed Abdul Barry --- Madhat Mahdi --- Lubna D Jafer

Basrah Journal of Surgery مجلة البصرة الجراحية
ISSN: 16833589 Year: 2010 Volume: 16 Issue: 2 Pages: 89-94
Publisher: Basrah University جامعة البصرة

Abstract

This study aimed to know the effect of serum calcium(Ca), inorganic phosphate(P), uric acid(UA), copper(Cu), zinc(Zn) and magnesium(Mg) on osteoarthritic (OA) patients who are havingpure OA of knee & those having diffuse OA (knee and spine), and to clarify the relationship ofthose parameters with severity of symptoms and radiological findings.This is a prospective case control study conducted at Basrah province through of a period of 9months from October 2001 to June 2002, during which 100 patients with different types of OAwere admitted to the Orthopedics Clinic of Basrah General Hospital. Their age ranged from 40to 68 years olds (24 males and 76 females), were allocated into 3 groups (mild, moderate andsever OA) according to their symptoms and radiological findings. On the other hand 80apparently heath subjects (23 males and 57 females). Their ages ranged from 40-70 years oldwere participated as a control group.Venous blood samples were collected from each subjects and patients participated in this studyfor measurements Ca, P, UA ,Cu, Zn and Mg by using standard methods.Among two age groups and in female patients serum Ca level was highly significantly lowered(p > 0.01) in patients with moderate OA of knee as compared with mild OA patients.Serum uric acid was significantly increased(p> 0.05) in patients having mild OA of knee ascompared with mild OA of (knee and spine) at age group . 55 years, the same results wasobserved in male patients as compared to the females group. Serum Cu and P levels were nonsignificantlyaltered (p< 0.05) in two types of OA among different age and sex groups. SerumZn levels was significantly lowered (P<0.05) in patients with moderate and mild OA of knee andin sever and moderate OA of knee and combined for serum Mg levels among different age andsex groups.On the basis of this study, it can be concluded that incidence of moderate OA were high andrepresent 58% of total numbers of patient studied who were at higher risk of significantlydecrease in the concentration of calcium, zinc and magnesium.