Study the anticancer activity of plant phenolic compounds

Abstract

This study was carried out to extract the phenolic compounds from tea leaves and pomegranate peel. It appeared that tea leaves contain 7 phenolic compounds: epigallocatechin-3-O-gallate, epigallocatechin, catechin, quercetin, myricitin, rutin, and gallic acid. Their concentrations were 8.9, 6.6, 2.4, 1.8, 1.4, 1.2, and 0.9 mg/g respectively. The total amount of phenolic compounds in tea leaves was 23.2 mg/g. The pomegranate peel contained 3 phenolic compounds: tannic acid, ellagic acid and gallic acid with a concentration of 2.0, 5.3, and 407 respectively. The total amount of phenolic compounds in pomegranate peel was 12.00 mg/g. Both tea leaves and pomegranate peel extracts inhibit the proliferation of two cancer cell lines, AMN3 and Hela with a concentration of 125, 250, and 500 ug/ml, and there was a positive concentration – effect relationship. The results were discussed according to the previously known biological effects of phenolic compounds.