Electrolytes & [H+] Disturbances in Peptic Ulcer Patients

Abstract

in the body even a very small pH changes are important and result in change in bodyphysiology . We describe in our study the presence of alteration in electrolytes and acid-basestatus in patients with peptic ulcer disease.The study was carried out over a period of three years. 273 patients with peptic ulcer diseasediagnosed on endoscopy , of these 228 duodenal ulcer and 45 gastric ulcer , in addition 84subjects were considered as a healthy control .20 ml of gastric juice obtained for analysis and 5 ml blood sample were taken and pHdetermination and[ H+ ]estimated by electric sensitive method including the use of electronicsensitive pH – meter. The pH – electrode was initially calibrated in buffer solution of pH 7 ( Ian1969 ). Also the total acidity of gastric effluents were estimated by titration to pH 7 with 0.1NaOH. The K+ and Na+ concentrations determined by using flame photometric method ( Sood1987) The results of the study show that DU patients had significantly lower gastric secretionpH and higher H+ concentration in the blood than normal control subjects and total acidity ofgastric secretion also was higher than control.