THE POSSIBLE RELATION BETWEEN HELICOBAC T ER PYLORI I INFECTION WITH_ BLOOD GROUPS , ANEMIA ANDPERIPHERAL LYMPHOCYTE ELEVATION A

Abstract

Biopsy were taken from 50 patients in order to cultivate Helicobacter pylori andblood samples to detect anemia , differential white blood eellcount and blood groups .The results showed that anemia was found in 48% of the patients while lymphocyteelevated in 44% of them , blood group 0 had the higher percentage ( 42% ) in thosepatients among the other blood group types" . ' . _ _INTRODUCTION -Helicobacter pylori is a gram-negative microorganism that secretes manysubstances including ammoina , mucolytic enzymes ( adhesins , catalase and urease ) andacid secrete inhibitory proteins.(8) In addition to that it secrets toxin like vacuolatingcytotoxin A (vacA).(7). - —Adhesin allows the organism to adhere , catalase might protect the organisum fromthe immune system , urease increase the secretion of gastrin which stimulate the intestinal‘tissues to grow faster , and so could result in increased cancer risk .Urease is reponsible forhydrolyzing urea to NH3 and CO2, and acts as also protective by forming an alkalinenvironment around the organism . The combination of NH3 ,_Co2 and inhibitory proteinsallows the bacteria to setup locallized pockets where it can neutralize even the acidity of' blood type 0 stomachsThe genetics of the secretor and non —-secretor system interact to alter anindividuals risk for ulcer. In several studies , non—secretors of ABO substances have beenfound to have significantly higher rate ofduodenal and peplic ulcer .( 8)fl._ pylori infection increases the percentage of peripheral lymphocytes above theupper limit of referential.values .(l0)e ' ‘Recent evidence suggests that fl_. pylori infection could cause iron deficiencyanemia ( IDA ).(2). Adolescent femal athletes may have development of [_{_.__pyloriassociated ( IDA ) which can be managed by Q pylori eradication (5 ) . H. pylori mayhave a role in causing IDA in school-age children (3 )

Keywords

Anemia, Gastrin, Urea