التغيرات الكروموسومية والفسيولوجية لدى مرضى ابيصاص الدم النيقياني الحاد AML في محافظة كربلاء

Abstract

The study amied to study some cytogenetic , and physiological sides in acute myeloid leukemia (AML) patients before and after chemotherapy in kerbalaproviens .The study cytogenetic testes include : chromosomal abberation (CA),Mitotic index (MI),Blast index (BI). The result show numerical chromosomal changes in one case from the studied cases before chemotherapy its :45,XY,(-1),del(1) ,another case after chemotherapy its 45,XY,t(9;22),In addition high level of MI mean and BI in patient before chemotherapy compared with the control decreased level of MI and high level of BI significantly after chemotherapy compared with their mean before chemotherapy while means of BI,MI stay high compared with control after therapy . The present study showed also Occur different chromosomal abnormalities in patient after chemotherapy. Measurement of erythropoietin ,ANP ,Microalbuminurea level, The study showed significant height(p<0.01) in three parameters levels before chemotherapy in male while female had significant height (p<0.05) before chemotherapy compared with control ,and significant hight in erythropoietin ,ANP, Microalbuminurea more after chemotherapy