Synthesis and Identification some of heterocyclic compounds from 2-Aminobenzimidazole

Abstract

Abstract This reserch involved hetrocyclic compounds such as (Thiazolidine derivatives , imidazolidin derivatives,oxazole derivatives, imidazole derivatives and pyridine derivatives) were prepared by reaction 2-aminobenzaldehyde with benzaldehyde derivatives (4-dimethylaminobenzaldehyde, furfural,vanillin) to get shiff base (1-3) , N-(4-(dimethylamino) benzylidene)-1H-benzo[d]imidazol-2-amine(1), N-(furan-2-ylmethylene)-1H-benzo[d]imidazol-2-amine(2), 4-(((1H-benzo[d]imidazol-2-yl) imino) methyl)-2-methoxyphenol (3) . The cyclization of (1-3) with α-aminoacid (glycine) give the corresponding 3-(1H-benzo[d] imidazol-2-yl)-2-(4-(dimethylamino) phenyl) imidazolidin-4-one (4), 3-(1H-benzo[d] imidazol-2-yl)-2-(furan-2-yl) imidazolidin-4-one (5) , 3-(1H-benzo[d] imidazol-2-yl)-2-(4-hydroxy-3-methoxyphenyl) imidazolidin-4-one (6) , and when cyclization of (1-3) with thioglycollicacid give the corresponding 3-(1H-benzo[d] imidazol-2-yl)-2-(4-(dimethylamino) phenyl) thiazolidin-4-one (7), 3-(1H-benzo[d]imidazol-2-yl)-2-(furan-2-yl) thiazolidin-4-one(8), 3-(1H-benzo[d] imidazol-2-yl) -2-(4-hydroxy-3-methoxyphenyl) thiazolidin-4-one (9) . As well as the reaction of 2 - Amino benzoimidazole with chloro acetyl chloride to get N-(1H-benzo[d] imidazol-2-yl)-2-chloroacetamide which reacts with urea , thiourea , thiosemicarbazide, 2-aminobenzimidazole, 2-aminopyridine give the corresponding N5-(1H-benzo[d] imidazol-2-yl) oxazole-2,5-diamine (11),N5-(1H-benzo[d] imidazol-2-yl) thiazole-2,5-diamine(12),N-(1H-benzo[d] imidazol-2-yl)-2-(2-carbamothioylhydrazinyl) acetamide(13),2-((1H-benzo[d] imidazol-2-yl) amino)-N-(1H-benzo[d] imidazol-2-yl) acetamide (14) , N-(1H-benzo[d] imidazol-2-yl)-2-(pyridin-2-ylamino) acetamide (15) ..All this compounds characterized by means of FT- IR ,and some of the compoundesby means 1H-NMR,and 13C-NMR and follow reaction by Rf - TLC and Measure ment melting point .