Comparison Between the Effect of Antimlarial Drug Produced by Local

Abstract

Local isolate of Streptomyces sp.1 showed ability to produce antimalarial activity against P.vivax, itcaused a great reduction in the number of the parasite. The inhibition percentages during 24 and 48 hourswere 60.90, 88.38 respectively. Purification of antimalarial agent produced by Streptomyces sp.1 was doneby extraction with ethylacetate followed by methanol, and application of gel filtration (Sephadex LH-20,Silica gel column) which resulted in brownish compound. This compound named as SAN 1.Drug, antibiotics and SAN1 inhibited the growth of P. vivax in vitro. The highest inhibition value (87.55%)was observed when 1000  g/ml of trimethoprim was added to cultural medium, followed by chloroquine,primaquine, chloramphenicol, tetracycline, streptomycin, SAN1, rifamycin, erythromycin, ampicillin withinhibition percent 86.09, 83.81, 81.74, 78.83, 78.66, 78.42, 75.10, 74.27 and 74.06% respectively