Light Microscopic Investigation of Developing Rat Teeth After Atenolol Drug Administration (Experimental Study)

Asmaa S Al-Douri

Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان
ISSN: 18121217 Year: 2011 Volume: 11 Issue: 18 Pages: 331-345
Publisher: Mosul University جامعة الموصل


Aims: To investigate the effect of atenolol drug on the formation and development of rat dentition of rat (histologically and histochemically). Materials and Methods: Albino Wister rats were divided into two main groups,. The control group and experimental group, each consisted of (9) pregnant rats, giv-en 1 ml distilled water and 10 mg atenolol (powder) suspended in 1ml distilled water , orally , as a single dose, respectively from 12 – 18 day of gestation, after delivery of pregnanent rats, 36 newborn were selected to be scarified at ages 1, 5. and 10 post nataly from each group. The specimens were pre-pared for processing and stained with H&E and alcian blue stains. Results: The treated groups showed obvious histological changes: delay in tooth germ formation, increase blood vascularity, disorganiza-tion of ameloblast and odontoblast cells, and delay in glycosaminoglycan synthesis. Conclusions: Atenolol drug delay the rat tooth development causing abnormal odontogenic changes and inhibits gly-cosaminoglycan synthesis.