Swelling Behavior of Cross-link PVA with Glutaraldehyde


The polymeric hydrogels composed of poly vinyl alcohol (m.wt 72000) andglutaraldehyde(5%,8% and 10%) , have been thermally prepared for the purpose of studyingtheir swelling and drug release behavior .The swelling ratio was measured for all the hydrogel samples at 37°C, in three differentmedia pH (1.2, 4.7 and 6.8) as a function of time. The results show that the maximumswelling ratios were arranged as follows :pH =6.8 > pH =4.7 > pH =1.2 hydrogels crosslinked PVA showed a typical pH responsive behavior such as high pH has maximumswelling while low pH shows minimum swelling