Cytotoxoic effect of Laurus nobilis extract on different cancer cell lines


Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Wstern counteries. Bay leaf has been used as herbal medicine and it has pharmacological activity, antibacterial, antifungal, antidiabetes, antiinflammatory effects and cytotoxic activities. In this stud, the effect of laurus nobilis hexan extract on three different cell lines was investigate in an attempt to identfy its potential activity. Cell viability and proliferation were assessed against different concentrations of laurus nobilis hexan extract (bay leaf) and reveled a remarkable inhibition of AMN3, REF and Hela cell lines in a dose dependent manner. Activity against AMN3 (mouse mammary adenocarcinoma), REF (rat emberyo fibroblast) and Hela (cervical human carcinoma cell line taken from Henrietta Lacks established 1951) was established with OD of 0.054, 0.05 and 0.1 respectively at the concentration 500 µg/ml with incubation period 24 h. The inhibition rate was 80%, 77% and 69 % for AMN3, REF and Hela respectively.