Frequency of HLA-DR3 Alleles and Pedigree Analysis for Patients with Thyroiditis

Abstract

A study was performed to estimation the concentration of HLA-DR3 alleles and pedigree analysis in patients with thyroid diseases in Babylon province .The results showed that there was significantly increased (p<0.05) in frequency of HLA-DR alleles in all groups of patients (hyperthyroidism , hypothyroidism , euthyroidism and normal with family history ) compared with healthy subjects . Furthermore , the results reveals increased ratio of disease in females compared with males , also the ratio of thyroiditis patients were higher in second age categories compared with first and third age categories . The pedigree analysis showed genetic role in the frequency of disease depending on the genetic history of family , where more patients with thyroiditis were found in families, one of them (especially mother) or their uncles undergo from this disease .