Study The Predictive Value Of Troponin –I And Histopathological Changes During Acute And Chronic Myocardial Infarction In Adult Male Rats.

Abstract

Our study used cryo-injury model to induce myocardial infarction in adult male rats by using liquid nitrogen (-196 co)and investigate the physiological changes during acute and chronic M.I through checking serum blood biomarker (Troponin-I), and doing scoring between the biomarker and the histopathological changes in rats myocardium in different period time We used a total of 35 adult male rats and divided them in to subgroups as following:•Fifteen rats for induced acute myocardial infarction (4/hr., 8/hr. 24/hr.).•Fifteen rats for induced chronic myocardial infarction (7/days, 14/days, 28/days).•Five rats as a control healthy group.Troponin-I increased significantly at 4 hours post experimental induction of myocardial infarction and persist significantly high for 7 days then decline later on.The histopathological changes during acute and chronic M.I reflect the physiological changes in concentration of cardiac biomarker (CTnI).On this results showed highly significant(P<0.01) increase in concentration levels of serum CTnI at 4/hr. post experimental induction of M.I this results means the importance of CTnI as highly specific and sensitive marker of myocardial necrosis ; and The histopathological changes during acute and chronic M.I it is close related with physiological changes occur in cardiac biomarker concentration and appear early in blood