Abstract Laparoscopic cholecystectomy has become the preferred choice of management for gallstone disease. In spite of various theories explored trying to assess different aspects of management and outcome to reach the acceptable safest technique in laparoscopic operation and to compare it with its counterpart. Many surgical methods were attempted to clarify their value in counteracting a serious complication of laparoscopic cholecystectomy, mainly is the bile duct injury. This study aimed to evaluate the significance of critical view of safety as a technique of laparoscopic cholecystectomy concerning the issue of preventing bile duct injury in regard to the infundibular technique of dissection. This is an observational study of two hundred fifty patients who were scheduled for laparoscopic cholecystectomy using critical view of safety technique compared with probably matched previously performed two hundred fifty of laparoscopic cholecystectomy using infundibular technique. The incidence of bile duct injury was analyzed in both groups. The results shows that age, sex, body mass index and gall bladder status were comparable in both groups. The Incidence of bile duct injury in infundibular technique was (1.6%), while in critical view of safety technique the incidence was 0% which is statistically significant (P<0.05). In conclusion, critical view of safety technique in laparoscopic cholecystectomy has a significant effect in preventing bile duct injury as compared to infundibular technique with comparable time of surgery and it is best to be the preferred technique in laparoscopic cholecystectomy.