Salivary IgA in chronic kidney disease patients undergoing hemodialysis in Missan governorate

Abstract

Background: Chronic kidney disease is a worldwide health problem, with adverse outcomes of cardiovasculardisease and premature death, can be divided into five stages, depending on how severe the damage is to thekidneys, or the level of decrease in kidney function, the final stage of chronic kidney disease is called end-stagerenal disease, salivary immunoglobulin A is the main immunoglobulin found in mucous secretions, including tears,saliva, colostrum and secretions from the genitourinary tract gastrointestinal tract, prostate and respiratoryepithelium. It is also found in small amounts in blood.This study aimedto measuresalivary flow rate andsalivaryimmunoglobulin Alevels in chronic kidney disease patients on hemodialysis treatment in comparison withhealthy control subjects.Materials and Methods: Ninety (90) subjects were participated in this study; 45 Patients undergoing hemodialysis withchronic kidney diseases; 45 health control subjects. Saliva collected was measured and levels of salivaryimmunoglobulin A were measured by Enzyme Link Immunosorbent Assay (Elisa).Results:The present studyrevealed that the mean value of salivary flow rate in chronic kidney disease patients was(0.34 ± 0.19) ml/min, while for healthy control subjects was (1.02 ± 0.39) ml/min, there wasstatisticallysignificantlydecrease in salivary flow rate ofchronic kidney disease on hemodialysis patients as compared to control healthysubjects.The present study revealed that the (Mean±SD) of the immunoglobulin A in chronic kidney disease patientson hemodialysis (388.81±227.86) μg./ml, while in control group (273.98±155.89) μg./ml, the result revealed statisticallysignificant increase in chronic kidney disease patients on hemodialysis as compared to control subjects.Conclusions: Salivary immunoglobulin (IgA) reflects the functional capacity of the glands. Increased concentrationof this component is usually marker of a poor general condition