Effect of some synthetic chemical compounds on Klebsiella pneumoniae

Abstract

One hundred and fifty five isolates were collected from maternity and children hospital who suffer from acute and chronic pneumonia. The effect of some synthesized chemical compounds such as N-pyridine-4-ythiourea and N-(5-phenyl-1 ,3,4-oxadiazole) -2-yl) urea was studied, on growth of K. pneumoniae which isolated from case above. Twenty percentage gave positive results for K. pneumoniae growth. The synthesized compounds appeared effect on growth of bacteria about and the effect was varied according to concentration used, by measuring of zone inhibition, N-pyridine-4-ythiourea in 100µg/ml were inhibted growth of K. pneumoniae in zone inhibition diameter (23±0.8) but when use 12.5µg/ml from about compound K. pneumoniae did not response, So when used 100µg/ml from N-(5-phenyl-1 ,3,4-oxadiazole) -2-yl) urea were inhibited growth of above bacteria by zone inhibition diameter (26±0.3) and 21±0.3, 19±0.9, 14±0.6 when used (50, 25 and 12.5) µg/ml respectively.