Synthesis and Antibacterial Activity Evaluation of Several New Sulfonamido Naphthalimides Linked to Benzothiazole or Oxadiazole

Abstract

In this work several new sulfonamido naphthalimides linked to benzothiazole or oxadiazolecycles were synthesized via multistep synthesis. The first step involved synthesis of compound [1]N-phenylnaphthalimide via reaction of aniline with naphthalic anhydride at high temperature in thepresence of glacial acetic acid. In the second step compound [1] was introduced in reaction withchlorosulfonic acid producing compound [2] 4-(N-naphthalimidyl) phenyl sulfonyl chloride whichinturn introduced subsequently in the third step in reaction with 2-amino-5-substituted-1,3,4-oxadiazoles producing the target naphthalimides [10, 11] or with substituted 2-aminobenzothiazolesproducing the target naphthalimides [12-16]. Results of antibacterial activity study of the newlysynthesized naphthalimides indicated that they posses high antibacterial activity.