Histological Study of Development Liver in Indigenous Rabbits Fetuses

Abstract

Twenty mature indigenous breed rabbits were used, the animals were divided into four groups(A, B, C, D, and E)each group composed of four female and one male according to times of embryonic study which included ( 6, 8, 10, 12, 14)days postnatal. This study showing the histological changes during the development of liver in early embryonic life by usingthe H&E Stain. The results at six day of gestation differentiation of some structures as a clusters of stem cells in deferentlocation of rabbit embryo. The cluster of stem cells will development into deferent organs in the next stage of development ofrabbit embryo. The result at eight day of gestation appear the liver as spherical structure near the heart development regionin addition to the appear of the other organs beside the fetal liver. At ten day of gestation the embryonic liver become moreprominent and differentiation inside the embryo. The twelve day of embryonic life the proliferation of hepatoblast andshowing in deferent figure of mitotic division. The result appear the primordial hepatoblast arranged as short hepatic cordsand located some of small lipid droplets in cytoplasm of hepatoblast. At fourteen day of gestation the hepatocytes arranged aslong hepatic cords, the lipid droplets disappear from the cytoplasm in addition to located high number of hematopoietic cellshave nucleus in blood stream, so the density of outer region of foetal liver more than the central region.