Synthesis and Characterization of new Mannich Bases for Pyrazole containing Benimidazole Ring

Abstract

This research includes synthesis of new derivatives of benzimidazole , the compound (A1*) prepared by reaction of o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then the compound (A1*) was reaction with ethyl chloroacetate and potassium hydroxide to give ester (A2*). Then preparation of hydrazide (A3*) by the reaction of (A2*) with hydrazine hydrate (80%). Then we used the hydrazide (A3*) to prepare pyrazole (A4), then preparation of mannich basses by reaction of compound (A4) with different primary aromatic amines and formaldehyde