Antioxidants improve Ankle-Brachial Index in Patients with Peripheral Vascular Disease

Abstract

Abstract:Objective: The study was designed to evaluate the effects of vitamin C (250mg/ daily ) plus vitamin E (100 mg/daily ) for three months on the ankle – brachial index (ABI) in 20 male patients with peripheral vascular disease (PVD) .Setting: Department of pharmacology and department of medicine , College of Medicine ,AL-Mustansiriyah University and AL-Yarmouk Teaching Hospital. Design: Prospective, randomized, intervention study .Outcome measures: Ankle –brachial index is calculated using Doppler ultrasound probe and standard sphygmomanometer .Results: Data showed that vitamin C plus vitamin E were statistically significant increase in the mean values of ABI after three months treatment in comparison with pretreatment values in patients with peripheral vascular disease. While the results of the treatment with aspirin (100mg / daily ) showed no significant difference in ABI after three months treatment in comparison with pretreatment values .Conclusion: Combined double therapy of daily vitamin C (250mg ) plus vitamin E (100 mg) can be useful and effective therapeutic strategy in treating patients with peripheral vascular disease.

Keywords

Vitamin C, Vitamin E, ABI, PVD