Clinical Analysis of Carcot Marie Toth Disease (CMTD) Cases

Abstract

Abstract :Objective: to evaluate Charcot Marie Tooth Disease CMTD cases attending Al-Kindi and Al-Yarmouk teaching hospital clinically and neurophysiologically and drew the family pedigree for each patient.Methods: sixty eight patients with CMTD ,belonging to 17 families were included in this study . Neurophysiological study were done for each patient according to which a demyelinating or an axonal type was said to be present and the seventeen families were plotted in pedigree and probable mode of inheritance was suggested for each family .Results: forty patients belonging to 10 families have a demyelinating type with an autosomal dominant mode of inheritance in 6 families and autosomal recessive mode in the rest 4 families. Twenty eight patients belong to 7 families have axonal polyneuropathy with autosomal dominant in 2 families and autosomal recessive in the rest 5 families .Conclusion: genetic counseling and family planning are needed in our community to offer a better understanding and prevent the growing of the problem .