Immunohistochemical Expression of P53 In Different Types of Ameloblastoma

Abstract

Introduction: Authors agree that ameloblastoma is a benign but aggressive tumor develops in the jaw area either from tooth bud epithelium, or the epithelial remnants left after tooth eruption or extraction. The WHO classified the Ameloblastoma, in its 2005 tumors classification, as a group of tumors, each one of tumors of this group has its own clinical behaviour and radiographic appearance. The local invasion and destruction of the adjacent structures are the source of risk in ameloblastoma. Nevertheless, a high rate of recurrence is reported after surgery. A lot of immunohistochemical researches have been conducted in the last two decades in an attempt to elucidate the etiologic factors and treatment modalities for this tumor. P53 gene plays a key role in cell cycle regulation and it has been shown as an important factor in the genesis of some types of this tumor that affects its behavior.
Aims of the Study: This study was carried out to investigate the association between P53 positivity and some types of ameloblastoma.
Materials and Methods: Twenty specimens of ameloblastoma have been studied immunohistochemically with p53 expression using monoclonal antibody (according to instruction of the Immunotech, Marseille, Codex-9-France).
Results: Observed tumor types were as follows: 7, follicular type, 5, plexiform type and 8 with unicystic type.
P53 was found to be positively expressed in 17 (85%) cases, and negatively in 3(15%) cases.
Conclusion: The unicystic type showed higher intensity of p53 expression which indicates higher rate of invasion and recurrence.

Keywords: Ameloblastoma ; P53 .