Immunological Study of Cytomegalovirus Infection in Women with Recurrent Fetal Loss in Ramadi City, West of Iraq

Abstract

Abstract

Objective: The aim of this study was to detected the role of anti-cytomegalovirus IgM and IgG antibodies in the diagnosis of CMV infection in women with recurrent fetal loss .
Patients and Methods : Eighty-seven sera were obtained from women suffering from recurrent fetal loss admitted to Maternity and Children Hospital in Ramadi during the period from September 2007 to June 2008 . Anti-Cytomegalovirus IgM and IgG antibodies were detected by ELISA Technique. The positive cases were tested again two weeks later to prevent seroprevalnce conversion.
Results : Out of the 87 asymptomatic pregnant women (33.3%) tested positive for the CMV specific IgM antibody and 28.5% positive for IgG antibody revealing primary infection during the first trimester and increasing the possibility of transmission of infection in uterus to the fetus .
Conclusion: The study concluded that screening of pregnant women, although, cannot change the outcome of the disease but may be useful in alerting the physician for possible infection to the baby. Hence routine screening of females of child bearing age for CMV infection is desired in order to reduce the fatal outcome of the pregnancy occurring due to the CMV infection

Keywords : Anti-CMV IgG , Anti-CMV IgM , recurrent Fetal loss .