ASSESSMENT OF INFLAMMATORY MARKERS AND MALONDIALDEHYDE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME

Abstract

ABSTRACTBackground and objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder ofunknown etiology characterized by anovulation and hyperandrogenemia associated withother symptoms mainly insulin resistance. The aim of the present study is to evaluate the roleof inflammation and oxidative stress in the pathogenesis of PCOS.Methods: Sixty clinically diagnosed PCOS women according to Rotterdam criteria and thirtyapparently healthy individuals have been included in this case control study. History andclinical examination were done along with laboratory tests. Statistical analysis was doneusing SPSS version 18 (Chicago, USA).Results: There were significant increases in inflammatory markers including high sensitivityCRP (P=0.001), total WBC count (P=0.03) and Erythrocyte sedimentation rate (P=0.001) inPCOS group compared to control subjects. Furthermore, mean serum malondialdehyde(MDA) level was significantly higher in PCOS patients (P=0.005) compared to controls.Conclusion: There is existence of low grade inflammation as well as oxidative stressrepresented by malondialdehyde that may play a pivotal role in PCOS pathogenesis.