Identification histopathological characterizations of mercuric chloride toxicity in albino male mice

Abstract

AbstractMercury compounds have been known as one of most heavy metals which cause adverse effect forboth human and animal. Nevertheless, several studies have been documented poison effect ofmercury in different aspects, but so far there are few reports related histopathlogical changes are notenough clear according dose-dependent. Therefore, our study focused on histopathlogicalexamination of kidney and lung tissues which were treated with two different dose of mercuricchloride to elucidate level of toxicity. Thirty male mice have been equally divided in to three groups.First group was treated with distilled water as control and other two groups were given two differentdoses of mercuric chloride; 1mgk.g and 4 mgk.g respectively. All animals have been administratedby intra-peritoneal injection for 60 consecutive days. At the end of experimental; all mice weresacrificed and eviscerated the target organs (kidney and lung) to prepare for histological processingsteps. Histopathlogical results have revealed that severity of low dose mercuric chlorideadministration was minor effect than high dose given in both kidney and lung. That was showingmoderate renal structures damages and pulmonary parenchyma destruction. Consequently, theseresults indicated that toxic activity of mercuric chloride was according to dose-dependent.Subsequently, the moderate damages have been occurred in renal and lung tissues due to long termexposure.