Synthesis and Characterization of Carboxymethyl Cellulose-g- poly(acrylamide) as Polymeric Drug Carrier

Abstract

The grafted acrylamide copolymerization on Carboxymethyl Cellulose (CMC) in aqueous media was synthesis and studied via ceric ammonium nitrate (CAN) with thiourea as initiators. The graft polymer was illustrated through FTIR, DSC, TGA and DTG analysis. The effect of the monomer ratio to CMC was examined at the optimal grafting conditions found. Swelling properties of both CMC and the grafted polymer also the degree of swelling as a function of time have been studied and calculated in diverse media to get the time needed to achieve maximum swelling. The new prepared polymers with the maximum grafting percentage, PG have been used as polymeric drug carrier for 2-deoxy-D-glucose, DOG in two different media also the amount of DOG release from the polymers was found via spectrofluorometer.