Abstract

Background: Several immunological parameters have been investigated in patients with chroniclymphocytic leukemia (CLL). Some of them are important in detecting the prognosis of thedisease.Objectives: the aim of this study was to evaluate the level of ZAP-70 and CD38 in patients withnewly diagnosed chronic lymphocytic leukemia.Materials and methods: The study was done on 50 patients with newly diagnosis CLL 36 maleand 14 female. CD38 and ZAP-70 were measured in patients by using flow cytometry. Thesepatients were divided according to Ria stage into 29 patients with group II, 21 patients with groupI, group I included Rai stage O, I, II in which the RBC and platelet counts are normal while groupII included Rai stage III and IV in which RBC and platelet count are low.Results: ZAP-70 and CD38 were significantly increased in patients with group II when comparedto group I. ZAP-70 and CD38 may be regarded as bad prognosis factor for CLL patients.Conclusion: From the results of the current study, we conclude that ZAP-70 and CD38high level in patients with chronic lymphocytic leukemia is associated with bad prognosis

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The article was added to IASJ on 2019-07-03

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