Relationship between CD69/CD3+ Ratio of activated T-cells and some immunological parameters for SLE patients

Abstract

Systemic lupus erythematosus (SLE) considered as one of the chronic auto-immune multi systemic diseases affects females rather than males especially during childbearing age. A fluctuating nature of SLE disease activity deprive this disease from any of monitoring test, at likewise both of SLE disease activity index (SLEDAI) criteria or even the laboratory analyses do not confirm such disease activity, especially when a patient have normal serological results although during the disease activity (flare). This study done as a case control study (retrospective study), where a total sample size included (86) freshly peripheral blood samples, which subdivided into: a first the disease group comprised from (66) blood samples voluntary obtained from SLE patients whose attended Al-Yarmouk teaching hospital and Al-karama teaching hospital during the period (October/2017-June/2018) after official approvals were obtained from health institutions. however, the disease group were be divided into active group (flare) and in active group (remission) according to SLE disease activity index (SLEDAI) criteria by a specialized consultant. while the second group included (18) blood samples obtained from healthy individuals (controls) whose matched with a disease group in gender and age.