Prepared some derivatives ketones of carbonyl α.ᵦ_ unsaturated compounds and study of biological activity

Abstract

The research include prepared two compound from carbonyl α- ᵦ unsaturated carbonyl comoundcalled ((chalcones)) have been prepared using Aromatic aldehydes with aliphatic ketone، then thestudy of the bilogic efficacy of these compounds and their effect on diabetes. Blood using laboratorymice،The results of the experiment showed a decrease in the level of glucose and cholesterol and triglyceridesin the serum of mice when treated with the first compound (1)، which is1-cyclohexyl-5-(4-(dimethylamino)cyclohexyl)penta-1،4-dien-3-one، as well as lower the level of glucose and lowercholesterol and similar to clycerides Triglycerides in rats when treated with the second compound (2)،which is 1-cyclohexyl-5 (4-nitrocyclohexyl) penta-1،4-dien-3-one compared to the first compound.