The protective effect of Eclipta alba leaf extract against the toxicity of lead acetate that induces hormonal disorders in female rabbits

Abstract

The present study was deigned to show the protective effect of Eclipta alba leaf extractagainst the toxicity of lead acetate. So, the study was used 16 female rabbits (New Zealand)that divide randomly to four groups (each group consist 4 rabbits), the first group was controlgroup administrated only normal diet and water, the second group administrated withlead acetate for month, the third group administrated with lead acetate and 50mg leaf extractfor month, the fourth administrated with lead acetate and 100mg leaf extract for month. Thefemale rabbits that administrated with lead acetate show significant decreased (P < 0.05) inthe levels of estrogen, progesterone, LH (Luteinizing hormone), FSH (Follicle stimulatinghormone), TSH (Thyroid stimulating hormone), T3 (Triiodothyronine), T4 (Thyroxin) andincreased in the level of testosterone compared with control group. The levels of estrogen,progesterone, LH, FSH, TSH, T3, T4 and testosterone still normal when the groups administratedwith lead acetate and Eclipta alba leaf extract together. The results suggested that theEclipta alba leaf extract may have a protective effect against the toxicity of lead acetate