تاثيرعقار الكلبنكلامايد Glibenclamide في بعض المعايير البايوكيميائية في مصل المرضى المصابين بداء السكري في كربلاء

Abstract

The present study include the effect of the drug Glibenclamide which is used for patient complaining from insulin- independent diabetic patients .Some biological signs for the male and female diabetic patient who use different doses of th drug (5&10 )Mg per day for apriod of time ranging from 3years to 5 years were stadied.Examples of those biological signs are (Glutamate pyruvat transaminase) (GPT), (Alkaline phosphates) (ALP), Gutamate oxalocetate transminase(GOT).The sample used in experiment is classified into four groups due to patients age they are :-1-First group includes those patients whose ages ranging from 30 to 39 years.2-Second group includes those patients whose ages ranging fro 40 to 49 years.3-The third group contains those patients whose ages ranging from 50 to 59 years.4-The fourth group consists of those patients whose ages surpassing 60 years.The results of the diabetic patients were compared with the control group which is classified to age –group that are similar to the experimental group The resulte were :•The research shows that there is significant(p≤0.05) increasing in the activity of the enzyme (GPT) with the first male-age group and the second one of the patients who have a dose of 5mg per day where as such sings of any effects do not appear on females from all age -groups .•The research shows that there is significant(p≤0.05) increasing in the activity of the enzme (GOT) with the males who take (10,5) mg per day for all third age –groups .But the increasing is allocated to the third age group for the females who use 5mg per day .However the increasing includes all the age-groups for the females who use 10 mg per day. •The research shows also that the level activity of (ALP) has decreased with the female users of 5mg per day for the first age-group ,the second age group and the fourth age group whereas the dose 10mg has caused decreasing for the second age –group as for the male- users from the first –age –group ,the (10mg) dose reaches an increasing at the significant (p≤0.05) per day but it has decreased with the third age –group.