دراسة تأثير عصير حب الرمان في الحد من تأثير المنتجات الايضية للفطر Aspergillus flavus على اثني عشري الأرانب البيضاء .

Abstract

Fifteen A.flavus isolates were isolated from apple fruits which appear on it symptoms of infection ,the results of our study showed 13 isolates (86%) from these isolates had ability to produce aflatoxins .The results showed that this metabolic products had substantial effects on duodenum of albino rabbit ,e.g. cause Focal Aggregate Inflammatory cells (Mast cells ) in villi of duodenum and swelling of villi cells at 100µL/Kg. Similar tendency took place at concentration 200 µL/Kg, in addition to necrosis and Vascular Congestion in mucosa layer, while at 300 µL/K dose more effect were happen than above doses e.g. Vascular Congestion in mucosa layer and complete degradation in villi . When another group of animals are treated with doses of metabolic product together with different doses of Punica juice ,the toxicity effects of metabolic products of A.flavus was reduced at all levels of doses, where the effect of juice was increased by arising doses amount ,the results showed that the (200) µL/Kg of juice prevent the swelling of villi cells, while aggregation of inflamintray cells remain in villi was not recovered with same concentration , but when the dose increased to (400 ,800) µL/Kg lead to prevent all toxic effect were caused by metabolic product in (200 and 400) µL/Kg