Study of clinical signs and blood parameters in male albino mice exposed to toxic doses of the Insecticide cypermethrin
Abstract
This study has shed light on clinical signs and blood picture to different toxic concentration of insecticide cypermethrin on 60 male albino mice which divided into three equal groups. First group (control group) dipping in distal water, second group: dipping form of cypermethrin concentration 1.6 ml / litter . while the third group : dipping from cypermethrin concentration 1.8 ml /litter , these animals were exposed for 8 weeks and various parameters were utilized in evaluating the effects of the insecticide (clinical signs , body weight , weight of internal organs and blood picture ) . The animals of second and third group Showed different clinical signs included: loss of appetite, sedation, standing still on corner of the cage, rubbing its nose and face with both hands no response to external stimulants, increased salivation, shivering, paralysis of limbs and diarrhea. These signs increased with the increasing doses and time of exposure, while the control group didn’t show any clinical signs. Second group showed significant decrease at p ≤0.05 in body weight of exposure till the end of experiment. While the decrease in the body weight appeared at first week of exposure for the third group. There was significant increase in mean liver weight of both treated groups but the third group record higher means in comparison with the second and the control group. Average weight of spleen showed significant decrease in both treatment groups in comparison with the control one. The average weight of lymph nodes showed significant increase at( p ≤ 0.05) when animals were dipped with cypermethrin concentration at 1.6 ,1.8 ml/litter in comparison with the control .The white blood cells count WBCs, showed significant decrease at( p ≤ 0.05) of both treatment when compared with the control group while the decrease in differential WBC in treatment group , while the decrease was more in third group than second one in comparison with control group . The decrease wase variable in count of neutrophils , monocytes , esinophils according dose of insecticide .
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