The Role of Serum C - reactive protein in Leukemic and Lymphomic Patients

Abstract

Abstract
Background : C-reactive protein is a sensitive major acute phase reactant in humans, whose synthesis in the liver is regulated by different cytokines . C-reactive protein is a common marker of inflammation plays a key role in the progression of human cancer.
Objective: To detect the level of C - reactive protein in sera of patients with leukemia and lymphoma (infected and uninfected with fungus).
Methods: Ninety six patients and hundred and fourteen control patients attended Medical city in Baghdad over period from Oct. 2005 to Dec.2005 were included in the study. Patients were divided into 2 groups according to the infected or uninfected with fungi, also 20 healthy volunteers were included in this study.
Results: The level of C - reactive protein in sera of patients was significant higher than the healthy control group (248.6+70.5) and (3.72+1.61) respectively with (p~0.05). Also the level of C - reactive protein in sera of patients was significant higher than the patients control group (54.3+28.14) with (p~0.05).
Conclusions: There was a significant increase in mean serum level of C - reactive protein in patients with fungal infections.
Key Words: C-reactive protein, fungi, leukemia, lymphoma.